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KMID : 0848020030060010008
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Journal of Korean Breast Cancer Society
2003 Volume.6 No. 1 p.8 ~ p.14
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Translational regulation : A Novel Target for Breast Cancer Therapy
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Abstract
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Translational initiation is regulated in respones to nutrient availabilty and growth stimuli and is coupled with cell cycle progression and cell growth. There is now growing body of evidence which suggests links between translational regulation and the disruption of cell behavior that results in the development and progression of cancer. mRNA translation can be overactivated in breast cancer through elF4E overexpression or abnormal activation of signal transduction pathways. Among them, rapamycin-sensitive signal transduction pathway (mTOR signaling pqthway) is now being studied as a novel target for cancer therapy. In this article, the basic principles of translational control, the alterations encountered in cancer and selected therapy targeting mTOR signaling pathway are reviewed and the preclinical study regarding the determinants of rapamycin sensitivity in breast cancer is presented in order to help elucidate new avenuse for breast cancer therapy.
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KEYWORD
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